57 Results for "

Leptoderris fasciculata (Benth.) Dunn

" in MedChemExpress (MCE) Product Catalog:
Products (57)

57 Results for "Leptoderris fasciculata (Benth.) Dunn" in MCE Product Catalog:

8
Eribulin mesylate
Eribulin mesylate
0 Images
8 Publications Verification
Cat. No.: HY-13442A
CAS No.: 441045-17-6
Purity:  99.91%
Synonyms: B1939 mesylate; E7389 mesylate; ER-086526 mesylate
Target:  

Microtubule/Tubulin Apoptosis

연구분야:  

Cancer

Eribulin mesylate is an inhibitor for microtubule. Eribulin mesylate inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate exhibits antitumor efficacy in mouse model .
8
Dihydrokaempferol
Dihydrokaempferol
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8 Publications Verification
Cat. No.: HY-N2897
CAS No.: 480-20-6
Category:  

Flavanonols Flavonoids Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Bcl-2 Family

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .
7
Tectorigenin
Tectorigenin
0 Images
7 Cited Publications
Cat. No.: HY-N0792
CAS No.: 548-77-6
Category:  

Flavonoids Leguminosae Pueraria lobate (Willd.) Ohwi Plants Disease Research Fields Inflammation/Immunology Cancer Isoflavones

Target:  

Others

Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria lobate Benth.
1
Kukoamine A
Kukoamine A
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1 Cited Publications
Cat. No.: HY-N2392
CAS No.: 75288-96-9
Category:  

Cardiovascular Disease Alkaloids other families Other Alkaloids Phenols Polyphenols Plants Disease Research Fields

Target:  

Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX

Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE2, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .
Orsellinic acid
Orsellinic acid
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Cat. No.: HY-N3126
CAS No.: 480-64-8
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Drug Derivative Fungal Apoptosis Caspase PARP

Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer) .
6-Bnz-cAMP sodium salt
6-Bnz-cAMP sodium salt
0 Images
Cat. No.: HY-103322
CAS No.: 1135306-29-4
Target:  

PKA Potassium Channel

연구분야:  

Metabolic Disease Cancer

6-Bnz-cAMP sodium, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K + channel. 6-Bnz-cAMP sodium does not activate the Epac signaling pathway. It inhibits the bTREK-1 K + channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP sodium activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. It can be used in studies related to bone tissue repair and regeneration .
Androsin
Androsin
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Cat. No.: HY-N1399
CAS No.: 531-28-2
Category:  

Ketones, Aldehydes, Acids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Inflammation/Immunology

Target:  

AMPK PI3K Autophagy

Androsin is an active compound isolated from Picrorhiza Kurroa Royle ex Benth. Androsin activates AMPKα/PI3K/Beclin1/LC3 signaling pathway, inhibits SREBP1c/FASN signaling pathway. Androsin can be used in research of asthma and non-alcoholic fatty liver disease (NAFLD). Androsin is orally active .
Praeruptorin E
Praeruptorin E
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Cat. No.: HY-N6066
CAS No.: 78478-28-1
Category:  

Cardiovascular Disease Salvia hypargeia Fisch. & C.A.Mey. Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields

Target:  

Calcium Channel NF-κB Pregnane X Receptor (PXR) Cytochrome P450 Interleukin Related

Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn. Praeruptorin E reduces the expression of NF-κB. Praeruptorin E upregulates the expression of PXR and CYP3A4. Praeruptorin E inhibits Th2 cytokines, TNF-α, IL6, MPO, and blocks the Ca 2+ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury .
Buddlejasaponin IVb
Buddlejasaponin IVb
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Cat. No.: HY-N2138
CAS No.: 152580-79-5
Category:  

Triterpenes Prosopis juliflora (Sw.) DC. Labiatae Dipsacaceae Terpenoids Dipsacus asper Wall. Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .
Humantenine
Humantenine
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Cat. No.: HY-N4031
CAS No.: 82375-29-9
Category:  

Alkaloids Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids

Target:  

Anaplastic lymphoma kinase (ALK) METTL3

Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD50 values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .
Frangulin A
Frangulin A
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Cat. No.: HY-N8344
CAS No.: 521-62-0
Category:  

Ventilago leiocarpa Benth. Quinones Anthraquinones Plants Rhamnaceae

Target:  

Others

Frangulin A is a emodin derivative. Frangulin A can be obtained from Ventilago leiocarpa Benth .
Thaumatins
Thaumatins
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Cat. No.: HY-W540600
CAS No.: 53850-34-3
Category:  

Marantaceae Thaumatococcus daniellii (Benn.) Benth. Natural Products Other Diseases Plants Disease Research Fields Sweeteners Food Research

Target:  

Environmental Pollutants

Thaumatins is a protein, which can be purified from the fruit of Thaumatococcus daniellii Benth. Thaumatins is 100,000 times sweeter than sucrose on a molar basis .
Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)
Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)
0 Images
Cat. No.: HY-13442C
CAS No.: 441045-17-6
Synonyms: B1939 mesylate (purity>99%, single impurity ≤ 0.15%); E7389 mesylate (purity>99%, single impurity ≤ 0.15%); ER-086526 mesylate (purity>99%, single impurity ≤ 0.15%)
Target:  

Microtubule/Tubulin Apoptosis

연구분야:  

Cancer

Eribulin (B1939; E7389; ER-086526) mesylate (purity>99%, single impurity ≤ 0.15%) is an inhibitor for microtubule. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) exhibits antitumor efficacy in mouse model .
Praeroside II
Praeroside II
0 Images
Cat. No.: HY-N7542
CAS No.: 86940-46-7
Category:  

Chrysanthemum × morifolium (Ramat.) Hemsl. Coumarins Phenylpropanoids Plants Umbelliferae

Target:  

HCV Protease

Praeroside II is an angular-type pyranocoumarm glycoside. Praeroside II can be isolated from the n-butanol-extracts of P. praeruptorum Dunn. Praeroside II can be used for pharmacological study .
Millepachine
Millepachine
0 Images
Cat. No.: HY-N7591
CAS No.: 1393922-01-4
Category:  

Flavonoids Chalcones Leguminosae Millettia pachycarpa Benth. Plants Disease Research Fields Cancer

Target:  

Apoptosis

Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .
Aurantiamide benzoate
Aurantiamide benzoate
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Cat. No.: HY-N10863
CAS No.: 150881-02-0
Category:  

Alkaloids Celastraceae Pyridine Alkaloids Celastrus rugosus Rehd. et Wils. Plants

Target:  

Xanthine Oxidase

Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC50 value of 70 μM .
N-2-Cyclohexylethyl-N-methylamine
N-2-Cyclohexylethyl-N-methylamine
0 Images
Cat. No.: HY-W193398
CAS No.: 62141-38-2
Target:  

Monoamine Oxidase

연구분야:  

Cardiovascular Disease

N-2-Cyclohexylethyl-N-methylamine is an amine from A.ridigula Benth for a reduction of monoamine oxidase (MAO) activity .
2-Hydroxy-1-methoxyanthraquinone
2-Hydroxy-1-methoxyanthraquinone
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Cat. No.: HY-N5125
CAS No.: 6170-06-5
Category:  

Quinones other families Monophenols Anthraquinones Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial

2-Hydroxy-1-methoxyanthraquinone could be isolated from the stem bark of Morinda lucida Benth. (Rubiaceae) and possesses antibacterial activity .
Rehmannioside B
Rehmannioside B
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Cat. No.: HY-N10694
CAS No.: 81720-06-1
Category:  

Plantaginaceae Iridoids Terpenoids Picrorhiza kurroa Royle ex Benth. Plants

Target:  

Others

Rehmannioside B is a desacyl derivative of Picrorhizaoside B, which can be isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae) .
Tectorigenin (Standard)
Tectorigenin (Standard)
0 Images
Cat. No.: HY-N0792R
CAS No.: 548-77-6
Category:  

Flavonoids Leguminosae Pueraria lobate (Willd.) Ohwi Plants Isoflavones

Target:  

Reference Standards Others

Tectorigenin (Standard) is the analytical standard of Tectorigenin. This product is intended for research and analytical applications. Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria lobate Benth.
Assay Types